Structural Modeling Insights into Human VKORC1 Phenotypes
نویسندگان
چکیده
منابع مشابه
Structural Modeling Insights into Human VKORC1 Phenotypes.
Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) catalyses the reduction of vitamin K and its 2,3-epoxide essential to sustain γ-carboxylation of vitamin K-dependent proteins. Two different phenotypes are associated with mutations in human VKORC1. The majority of mutations cause resistance to 4-hydroxycoumarin- and indandione-based vitamin K antagonists (VKA) used in the prevention an...
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ژورنال
عنوان ژورنال: Nutrients
سال: 2015
ISSN: 2072-6643
DOI: 10.3390/nu7085313